The 34-year-old man, who was not identified, experienced a series of intense headaches and dry heaving after eating a Carolina Reaper, reportedly the hottest pepper in the world, during the contest in New York.
When the patient arrived at the hospital, physicians were not positive what had caused his symptoms. The man did not have any neurological deficits such as slurred speech, muscle weakness or vision loss that would have indicated a stroke. CT imaging also ruled out a blood clot or bleeding in one of the large blood vessels supplying the brain.
But a CT angiogram of the brain’s blood vessels did reveal something unusual: a substantial narrowing of the left internal carotid artery and four other blood vessels supplying the brain.
“Then CT angiography was done, which showed narrowing of the blood vessels in the brain,” Gunasekaran said. “You could see the beaded appearance [of the arteries], and the yellow arrows point to the narrowing of the blood vessels.”
Gunasekaran and Dr. Gregory Cummings, the neurologist on the case, eventually diagnosed the man with reversible cerebral vasoconstriction syndrome, or RCVS, probably caused by the hot peppers.
It is normally associated with certain medications, such as ergotamine or triptans, and illicit drugs, such as cocaine and amphetamines — not peppers. Severe cases can even be life-threatening, according to Ducros.
“A proportion of patients will have a severe form with strokes, and they can get either an intracranial hemorrhage of an ischemic stroke,” Ducros said. “But the mortality is low, around 2% … and most patients who die from RCVS are young women and often in the postpartum state.
“But most of them will do well with only recurrent headaches, and then they have a total recovery,” she added.
Hot peppers have a high concentration of capsaicin, a chemical responsible for the spiciness of certain foods. The substance is known to cause constriction of blood vessels in some parts of the body and is even used at low concentrations in some topical medications.
But this would be the first documented case of hot peppers causing vasoconstriction in the brain, according to the report.
“This is the first time that pepper has been related to RCVS,” Gunasekaran said. “Capsaicin, the key ingredient in the pepper, is a vasoactive substance, so it could potentially narrow the blood vessels to the most important organs like the heart and brain.”
According to Ducros, RCVS can also be triggered by extreme emotions or pain, which may have played a role in the case of the hot pepper contestant.
“You can also have RCVS after strong emotion, such as learning the death of a friend,” Ducros said. “The mechanism is that strong emotion can activate the sympathetic tone, and this leads to vasoconstriction.”
Sympathetic tone refers to the activation of the sympathetic nervous system, which also results in the constriction of blood vessels.
“For example, in the case of ingestion of pepper, perhaps it is the intense pain triggered by the pepper which triggered the RCVS and not the pepper itself,” Ducros added.
Treatment for RCVS typically consists of removal of the offending substance and supportive care such as pain management, she said.
In this case, the patient’s symptoms improved, and he was released from the hospital after a few days.
“The patient was followed up after five weeks, and a repeat CT angiography showed resolution of the narrowing of the blood vessels,” Gunasekaran said. “Usually, RCVS resolves on its own after days to weeks.”
The authors of the report advise that RCVS should be considered for patients who experience intense headaches after eating hot peppers, cayenne pepper or any other substance containing high amounts of capsaicin.
“It’s important to think about RCVS if you get a very severe and instantaneous headache. It’s the main cause after a subarachnoid hemorrhage,” Ducros said. “But, unfortunately, this condition is still not widely known.”
News credit : Cnn